Limborska Svetlana Andreevna | Institute of Molecular Genetics

Limborska Svetlana Andreevna

Academic degree:
Doctor of Biological Sciences

Academic title:
Professor


Division of IMG:
Laboratory of molecular human genetics

Position:
Head of Department


Telephone:
+7-499-196-00-03

Е-mail:


Main research interests

- Ethnic genomic of Russia and neighboring countries
- Molecular genetics of inherited and multifactorial diseases.
- The transcriptome analysis of different tissue calls at health, ischemia and when pharmacologic effects
- Molecular genetics basis for different reaction of patients under platinum drug chemotherapy of oncology diseases
 
A molecular genetic characterization of populations of Eastern Europe have been carried out with the help of a large number of different DNA markers. The differences allow to assess the relationship and the degree of genetic proximity of populations to identify the features of their ethnogenesis were obtained (Limborska et al., 2002, 2011; Popova et al., 2001; Belyaeva et al., 1999, 2003; Verbenko et al., 2003- 2006; Nelis et al., 2009; Khrunin et al., 2009; Mirabal et al., 2009; Limborska et al. 2011; Esko et al., 2012). A significant correlation found between the frequency of allelic variants and haplotypes with climate-geographical parameters in the study region (Northern Eurasia), which indicates their role in adaptation (Limborska et al., 2002, 2009; Khrunin et al., 2005, 2007, 2010; Flegontova et al., 2009; Fillipova et al., 2012). A new branch in the genetic gene pool was revealed in Europe, which is characteristic for the far north-east regions of East European Plain. It is shown that the Russian population of the center of the East European Plain (Kursk, Murom, Tver) proved genetically very similar to each other and to the populations of Eastern and Central Europe. There was a significant difference between the Russian European North from the "central" Russian (Khrunin et al., 2013).
 
Using DNA microarrays the relationship between polymorphisms of genes related to important sites of metabolism of cisplatin and the efficacy and toxicity of chemotherapy based on it in ovarian cancer patients of Russian and Yakut ethnic groups was studied. All of the identified associations between polymorphisms and those or other clinical signs were specific for each of the groups. This suggests the presence of ethnic features in the molecular mechanisms of the reactions that determine the patient's sensitivity to the action of cis-platinum (Khrunin et al., 2010, 2012).
 
We have isolated from human brain cDNA library new gene MOB (TMEM23, SMS1), actively functioning in the brain cells, and encodes an enzyme sfingomielinsintaze I. The genes localization on the chromosomes was determined, and expression patterns in different tissues were studied (Vladychenskaya et al., 2002, 2004; Dergunova et al., 2003; Raevskaya et al., 2005). The structure of gene and the alleged discovery of the gene promoter regions were characterized. New variants of SMS1 human gene transcripts encoding the full-length protein, as well as transcripts arising from alternative combinations of exons and encode a truncated protein product were revealed. Tissue specificity of expression of alternative gene transcripts SMS1 is detected. The cloning of cDNAs containing the full and truncated transcripts of SMS1, into the vector pEGFP-C2 and expressed in Vero cells allowed to locate the full-length and truncated versions of the protein in the Golgi complex (Rozhkova et al., 2011). It was shown that the regulation of gene SMS1 expression is performed at the transcriptional, post-transcriptional and translational levels (Rozhkova et al., 2013).
The influence of synthetic peptides semaks and Pro-Gly-Pro on the transcripts of rat brain in experimental focal brain ischemia have been done. It is shown that semaks and Pro-Gly-Pro affect the expression of a large number of genes associated with a variety of biological processes that facilitate operation of the various systems. The immunomodulatory effect of Semax was shown as well as its effects on the vascular system in the conditions of ischemia, which are perhaps the key links of the neuroprotective effect of the drug in the treatment of stroke (Dmitrieva et al., 2008; Dmitrieva et al., 2010; Stavchansky et al., 2011 ; Stavchansky et al., 2011; Medvedeva et al., 2013).
 


Teaching activities

Lecture course "Molecular genetics of inherited neurological diseases," Medico-Biological Faculty of the Russian National Research Medical University named after NI Pirogov
Lecture course "Molecular genetics with the basics of modern biotechnology", Russian Chemical-Technological University named after DI Mendeleev
The head of more than 25 PhD and 4 Doctoral theses


Awards, achievements, memberships

1980 – The winner of the Lenin Komsomol Prize in for her work on the structure of the genome by genetic engineering
1989 –  Awarded the Silver Medal of ENEA
1996 - State Prize Laureate for the development of theoretical and applied problems of DNA fingerprinting
2012 and 2013 – Diplomas of the Federal Service for Intellectual Property in the "100 best inventions of Russia".
 
Member of NI Vavilov Society of Geneticists and Breeders (VOGIS), Russian Society of Medical Geneticists (ROMG), Russian Biochemical Society (DBR), the American Society of Human Genetics (ASHG), the European Society of Human Genetics (ESHG), International Human Genome Organization (HUGO), European Association of anthropologists (EAA). Member of the editorial boards of the journals "Russian journal of Genetics", "Molecular Genetics, Microbiology and Virology", "Medical Genetics", “Proceedings of the Latvian Academy of Sciences”.



Publications

  1. Limborska S.A., Korneev S.A., Maleeva N.E., Slominsky P.A., Jincharadze A.G., Ivanov P.L., Ryskov A.P. Cloning of Alu-containing cDNAs from human fibroblasts and identification of small Alu+poly(A)+ RNAs in a variety of human normal and tumor cells. FEBS Lett, Vol. 212, N2, p.208‑212, 1987
  2. Ryskov A.P., Jincharadze A.G., Prosnyak M.I., Ivanov P.L., Limborska S.A. M13 phage DNA as a universal marker for DNA fingerprinting of animals, plants and microorganisms. FEBS Lett, V 233, N2, p.388-392, 1988
  3. Stewart E.A., White A., Tomfohrde J., Osborne-Lawrence S., Prestidge L., Bonne-Tamir B., Scheinberg I. H., St George-Hyslop P., Giagheddu M., Kim J.-W., Seo J. K., Lo H.-Y., Ivanova-Smolenskaya I.A., Limborska S.A., Cavalli-Sforza L. L., Farrer L. A., Bowcock A. M. Polymorphic  microsatellites and Wilson disease. Amer. J. Hum. Genet., V 53, N4, p.864‑873, 1993
  4. Prosnyak M.I., Veselovskaya S.I., Myasnikov V.A., Efremova E.J., Potapov V.K., Limborska S.A., Sverdlov E.D. Substitution of 2‑aminoadenine and 5‑methylcytosine for adenine and cytosine in hybridization probes increases the sensitivity of DNA fingerprinting. Genomics, V 21, p.490‑494, 1994
  5. Kalnin V.V., Kalnina O.V., Prosniak M.I., Khidiatova I.M., Khusnutdinova E.K., Raphicov K.S., Limborska S.A. Use of DNA fingerprinting for human population genetic studies. Mol. Gen. Genet., V 247, N1, p.488‑493, 1995
  6. Potapov V.K., Azhikina T.L., Demin V.V., Sverdlov E.D., Limborska S.A. Modified oligonucleotides as a tool for DNA sequencing, fingerprinting and mapping. Pure Appl. Chem.,  V 68,  N6 p.101-105, 1996
  7. Illarioshkin S.N., Ivanova-Smolenskaya I.A., Tanaka H., Vereshchagin N.V., Markova E.D., Poleshchuk V.V., Lozhnikova S.M., Sukhorukov V.S., Limborska S.A., Slominsky P.A., Bulayeva K.B., Tsuji S. Clinical and molecular analysis of a large family with three disticnct phenotypes of progressive muscular dystrophy. Brain, v. 119, p.1120-1141, 1996.
  8.  Ozelius L.J., Hewett J., Kramer P., Bressman S.B., Shalish C., de Leon D., Rutter M., Risch N., Brin M.F., Markova E.D., Limborska S.A., Ivanova-Smolenskaya I.A., McCormick M.K., Fahn S., Buckler A.J., Gusella J.F., Breakefield X.O. Fine localization of the torsion dystonia gene (DYT1) on human chromosome 9q34. Genome Res., V.7, N5, p.483-494, 1997
  9.  Klein C., Brin M.F., de Leon D., Limborska S.A., Ivanova-Smolenskaya I.A., Bressman S.B., Friedman A., Markova E.D., Risch N.J., Breakefield X.O., Ozelius L.J. De novo mutations (GAG deletion) in the DYT1 gene in two non-Jewish patients with early- onset dystonia. Hum. Mol. Genet., V.7, N7, p. 1133-1136, 1998
  10.  Illarioshkin S.N., Markova E.D., Slominsky P.A., Miklina N.I., Popova S.N., Limborska S.A., Tsuji S., Ivanova-Smolenskaya I.A. The GTP cyclohydrolase I gene in Russian families with dopa-responsive dystonia. Arch. Neurol., V.55, N6, p. 789-792, 1998
  11. Belyaeva O.V., Balanovsky O.P., Ashworth L.K., Lebedev Yu.B., Spitsyn V.A., Guseva N.A., Erdes Sh., Mikulich A.I., Khusnutdinova E.K., Limborska S.A. Fine mapping of a polymorphic CA repeat marker on human chromosome 19 and its use in population studies. Gene, V.230, N2, p.259-266, 1999
  12. Slominsky P.A., Shadrina M.I., Kondratyeva E.A., Typitsina T.V., Levitsky G.N., Skvortsova V.I., Limborska S.A. Cu,Zn-superoxide dismutase gene in sporadic amyotrophic lateral sclerosis patients from Russia: Asp90Ala(D90A) mutation and novel rare polymorphism IVS3+35 A>C. Human Mutation, v.16, N3, 227-228, 2000
  13.  Pogoda T.V., Krakhmaleva I.N., Lipatova N.A., Shakhovskaya N.I., Shishkin S.S., Limborska S.A. High incidence of 550delA mutation in LGMD2 patients from Russia. Human Mutation, v.15, N3, 395-401, 2000
  14.  Semino O., Passarino G., Oefner P.J., Lin A.A., Arbuzova S., Beckman L.E., de Benedictis G., Francalacci P., Kouvatsi A., Limborska S., Marcikiae M., Mika A., Mika B., Primorac D., Santachiara-Benerecetti A.S., Cavalli-Sforza L.L., Underhill P.A. The genetic legacy of Paleolithic Homo sapiens sapiens in extant Europeans: a Y chromosome perspective. Science. 2000. Vol.290, N5494. p.1155-1159
  15. Shadrina M.I., Dolotov O.V., Grivennikov I., Slominsky P.A., Andreeva L.A., Inosemtseva L.S., Limborska S.A., Myasoedov N.F. Rapid induction of neurotrophin mRNAs in rat glial cell cultures by Semax, an adrenocorticontropic hormone analog. Neuroscience letters. 2001. Vol.308, p.115-118
  16. Spitsyn V., Khorte M., Pogoda T., Slominsky P., Nurbaev S., Agapova R., Limborska S.A. Apolipoprotein B 3’-VNTR polymorphism in the Udmurt population. Human Heredity, V.50, N4, 224-226, 2000
  17. Popova S.N., Slominsky P.A., Pocheshnova E.A., Balanovskaya E.V., Tarskaya L.A.,  Bebyakova NA., Bets L.V., Ivanov V.P.,  Livshits L.A., Khusnutdinova E.K., Spitsyn V.A., Limborska S.A. Polymorphism of trinucleotide repeats in loci DM, DRPLA and SCA1 in East European populations. European Journal of Human Genetics. 2001. Vol.9, N11. p. 829-835
  18. Verbenko D.A., Pogoda T.V., Spitsyn V.A., Bets L.V., Pocheshkhova E.A., Balanovskaya E.V., Bebyakova N.A., Ivanov V.P., Abolmasov N.N., Tarskaia L.A., Sorensen M.V., Limborska S.A.  Apolipoprotein B 3’-VNTR polymorphism in Eastern European populations. European Journal of Human Genetics. 2003. Vol.11, N6. p.444-451.
  19. Verbenko D.A., Kekeeva T.V., Pogoda T.V., Khusnutdinova E.K., Mikulich A.I., Kravchenko S.A., Livshits L.A., Bebyakova N.A., Limborska S.A. Allele frequencies for D1S80 (pMCT118) locus in some East European populations. ASTM Journal of Forensic Science. 2003. Vol.48, N1, 207-208
  20. Shabrova EV, Khusnutdinova EK, Tarskaia LA, Mikulich AI, Abolmasov NN, Limborska SA. DNA diversity of human populations from Eastern Europe and Siberia studied by multilocus DNA fingerprinting. Mol Genet Genomics. 2004. Vol.271. P. 291-297.
  21. Verbenko D.A., Pocheshkhova E.A., Balanovskaya E.V., Marshanija E.Z., Kvitzinija P.K., Limborska S.A. Polymorphisms of D1S80 and 3’ApoB minisatellite loci in Northern Caucasus Populations. ASTM Journal of Forensic Science. 2004. Vol. 50, N1. P. 180-182.
  22. V. Skvortsova, M. Shadrina, P. Slominsky, G. Levitsky, E. Kondratievа, A. Zherebtsova, N. Levitskaya, A. Alekhin, A. Serdyuk, S. Limborska. Analysis of heavy neurofilament subunit gene polymorphism in Russian patients with sporadic motor neuron disease (MND).  European Journal of Human Genetics. 2004. Vol. 12, N3. P. 241-244.
  23. Skvortsova VI, Slominsky PA, Gubskii LV, Koltsova EA, Shetova IM, Platonova IA, Tupitsyna TI, Khrunin AV, Limborska SA. Connection between p53 gene Bam HI RFLP polymorphism with the volume of brain infarction in patients with carotid atherothrombotic ischemic stroke. Restor Neurol Neurosci. 2004. Vol. 22. P. 81-85.
  24. Vladychenskaya IP, Dergunova LV, Dmitrieva VG, Limborska SA. Human gene MOB: structure specification and aspects of transcriptional activity. Gene. 2004; Vol. 338, N2. p.257-265.
  25. Khrunin AV, Tarskaia LA, Spitsyn VA, Lylova OI, Bebyakova NA, Mikulich AI, Limborska SA. p53 polymorphisms in Russia and Belarus: correlation of the 2-1-1 haplotype frequency with longitude. Mol Genet Genomics. 2005. Vol. 272, N6. P.666-672.
  26. Raevskaya N.M., Dergunova L.V., Vladychenskaya I.P., Stavchansky V.V., Oborina M.V., Poltaraus A.B.,  Limborska S.A. Structural organization of the human complexin 2 gene (CPLX2) and aspects of its functional activity. Gene. 2005. V.359. P.127-137.
  27. Verbenko D.A., Knjazev A.N., Mikulich A.I., Khusnutdinova E.K., Bebyakova N.A., Limborska S.A. Variability of the 3'APOB minisatellite locus in Eastern Slavonic populations. Hum. Hered. 2005. V.60. P.10-18.
  28. Verbenko D.A., Slominsky P.A., Spitsyn V.A., Bebyakova N.A., Khusnutdinova E.K., Mikulich A.I., Tarskaia L.A., Sorensen M.V., Ivanov V.P., Bets L.V., Limborska S.A. Polymorphisms at locus D1S80 and other hypervariable regions in the analysis of Eastern European ethnic group relationships. Ann Hum Biol. 2006. 33(5-6):570-58
  29. Shadrina M, Nikopensius T, Slominsky P, Illarioshkin S, Bagyeva G, Markova E, Ivanova-Smolenskaia I, Kurg A, Limborska S, Metspalu A. Association study of sporadic Parkinson's disease genetic risk factors in patients from Russia by APEX technology. Neurosci Lett. 2006. 405(3):212-216.
  30. S. N. Illarioshkin, M. I. Shadrina, P. A. Slominsky, E. V. Bespalova, T. B. Zagorovskaya, G. Kh. Bagyeva, E. D. Markova, S. A. Limborska and I. A. Ivanova-Smolenskaya. A common leucine-rich repeat kinase 2 gene mutation in familial and sporadic Parkinson’s disease in Russia. European Journal of Neurology 2007. 14(4):413-7
  31. Agapova TY, Agniullin YV, Shadrina MI, Shram SI, Slominsky PA, Lymborska SA, Myasoedov NF. Neurotrophin gene expression in rat brain under the action of Semax, an analogue of ACTH 4-10. Neuroscience Letters. 2007. 417(2):201-5.
  32. Shadrina MI, Semenova EV, Slominsky PA, Bagyeva GH, Illarioshkin SN, Ivanova-Smolenskaia II, Limborska SA. Effective quantitative real-time polymerase chain reaction analysis of the parkin gene (PARK2) exon 1-12 dosage. BMC Medical Genetics. 2007. 8:6.
  33. Khrunin A.V., Verbenko D.A., Nikitina K.V., Limborska S.A. Regional differences in the genetic variability of Finno-Ugric speaking Komi populations. American Journal of Human Biology, 2007, 19(6):741-50.
  34. V.G. Dmitrieva, E.V. Torshina, V.V. Yuzhakov,  O.V. Povarova, V.I. Skvortsova, S.A. Limborska, L.V. Dergunova.  Expression of sphingomyelin synthase 1 gene in rat brain focal ischemia.  Brain Research, 2008. Vol 1188:222-7.
  35. Khrunin A, Mihailov E, Nikopensius T, Krjutškov K, Limborska S, Metspalu A.  Analysis of allele and haplotype diversity across 25 genomic regions in three Eastern European populations  Human Heredity 2009 V.68. № 1. pp. 35-44.
  36. Flegontova OV, Khrunin AV, Lylova OI, Tarskaia LA, Spitsyn VA, Mikulich AI, Limborska SA. Haplotype frequencies at the DRD2 locus in populations of the East European Plain  BMC Genet. 2009 Sep 30;10:62.
  37. Nelis M, Esko T, Mägi R, Zimprich F, Zimprich A, Toncheva D, Karachanak S, Piskácková T, Balascák I, Peltonen L, Jakkula E, Rehnström K, Lathrop M, Heath S, Galan P, Schreiber S, Meitinger T, Pfeufer A, Wichmann HE, Melegh B, Polgár N, Toniolo D, Gasparini P, D'Adamo P, Klovins J, Nikitina-Zake L, Kucinskas V, Kasnauskiene J, Lubinski J, Debniak T, Limborska S, Khrunin A, Estivill X, Rabionet R, Marsal S, Julià A, Antonarakis SE, Deutsch S, Borel C, Attar H, Gagnebin M, Macek M, Krawczak M, Remm M, Metspalu A. Genetic structure of Europeans: a view from the North-East  PLoS ONE. 2009;4(5):e5472.
  38. Mirabal S, Regueiro M, Cadenas AM, Cavalli-Sforza LL, Underhill PA, Verbenko DA, Limborska SA, Herrera RJ.  Y-chromosome distribution within the geo-linguistic landscape of northwestern Russia. Eur J Hum Genet. 2009 V.17, №10, P. 1260-73.
  39. Dmitrieva V.G, Povarova O.V., Skvortsova V.I, Limborska S.A., Myasoedov N.F., Dergunova L.V. Semax and Pro-Gly-Pro Activate the Transcription of Neurotrophins and Their Receptor Genes after Cerebral Ischemia. Cell Mol Neurobiol. 2010; 30(1):71-79.
  40. Shadrina M.I., Filatova E.V., Karabanov A. V., Slominsky P.A, Illarioshkin S.N., Ivanova-Smolenskaya I. A., Limborska S. A. Expression analysis of suppression of tumorigenicity 13 gene in patients with Parkinson’s disease. Neuroscience Letters. 473(3), 2010, 257–259.
  41. Shadrina M, Kolomin T, Agapova T, Agniullin Y, Shram S, Slominsky P, Lymborska S, Myasoedov N. Comparison of the Temporary Dynamics of NGF and BDNF Gene Expression in Rat Hippocampus, Frontal Cortex, and Retina Under Semax Action. J Mol Neurosci. 2010; 41:30-35.
  42. Shadrina MI, Slominsky PA, Limborska SA. Molecular mechanisms of pathogenesis of Parkinson's disease. Int Rev Cell Mol Biol. 2010; 281: 229-66.
  43. Khrunin AV, Moisseev A, Gorbunova V, Limborska S. Genetic polymorphisms and the efficacy and toxicity of cisplatin-based chemotherapy in ovarian cancer patients. Pharmacogenomics J. 2010, 10(1):54-61.
  44. Stavchansky VV, Yuzhakov VV, Botsina AY, Skvortsova VI, Bondurko LN, Tsyganova MG, Limborska SA, Myasoedov NF, Dergunova LV. The Effect of Semax and Its C-End Peptide PGP on the Morphology and Proliferative Activity of Rat Brain Cells During Experimental Ischemia: A Pilot Study. J Mol Neurosci. 2011,45(2):175-185.
  45. Limborska S.A., Khrunin A.V., Flegontova O.V., Tasitz V.A., Verbenko D.A. Specificity of genetic diversity in D1S80 revealed by SNP–VNTR haplotyping. Annals of Human Biology, 2011, Vol.38, N5, pp.564-569
  46. T. Kolomin, M. Shadrina, L. Andreeva, P. Slominsky, S. Limborska, N. Myasoedov. Expression of inflammation-related genes in mouse spleen under tuftsin analog Selank. Regulatory Peptides. 2011, 170 :18–23.
  47. Rozhkova AV, Dmitrieva VG, Zhapparova ON, Sudarkina OY, Nadezhdina ES, Limborska SA, Dergunova LV. Human sphingomyelin synthase 1 gene (SMS1): Organization, multiple mRNA splice variants and expression in adult tissues. Gene. 2011, 481(2): 65-75.
  48. Pivovarova O, Fisher E, Dudziak K, Ilkavets I, Dooley S, Slominsky P, Limborska S, Weickert MO, Spranger J, Fritsche A, Boeing H, Pfeiffer AF, Rudovich N. A polymorphism within the connective tissue growth factor (CTGF) gene has no effect on non-invasive markers of beta-cell area and risk of type 2 diabetes. Dis Markers. 2011, 31(4): 241-6. doi: 10.3233/DMA-2011-0823.
  49. Filippova IN, Khrunin AV, Limborska SA. Analysis of DNA variations in GSTA and GSTM gene clusters based on the results of genome-wide data from three Russian populations taken as an example. BMC Genet. 2012,13(1):89.
  50. Khrunin A., Ivanova F., Moisseev A., Khokhrin D., Sleptsova Yu., Gorbunova V., Limborska S. Pharmacogenomics of cisplatin-based chemotherapy in ovarian cancer patients of different ethnic origins. Pharmacogenomics, 2012, 13 (1).
  51. Semenova EV, Shadrina MI, Slominsky PA, Ivanova-Smolenskaya IA, Bagyeva G, Illarioshkin SN, Limborska SA. Analysis of PARK2 gene exon rearrangements in Russian patients with sporadic Parkinson's disease. Mov Disord. 2012,27(1):139-42
  52. Medvedeva EV, Dmitrieva VG, Povarova OV, Limborska SA, Skvortsova VI, Myasoedov NF, Dergunova LV. Effect of semax and its C-terminal fragment Pro-Gly-Pro on the expression of VEGF family genes and their receptors in experimental focal ischemia of the rat brain. J Mol Neurosci. 2013 Feb;49(2):328-33. doi: 10.1007/s12031-012-9853-y.
  53. Maria I. Shadrina, Elena V. Filatova, Anelya Kh. Alieva, Alla V. Stavrovskaya, Rudolph M. Khudoerkov, Svetlana A. Limborska, Sergei N. Illarioshkin, Petr A. Slominsky, «Transcriptome profiling of 6-OHDA model of Parkinson’s disease». Advances in Bioscience and Biotechnology, 2013, 4, pp. 28-35. doi: 10.4236/abb.2013.46A005
  54. Dergunova LV, Rozhkova AV, Sudarkina OY, Limborska SA. The use of alternative polyadenylation in the tissue-specific regulation of human SMS1 gene expression. Mol Biol Rep. Dec;40(12):6685-90. doi: 10.1007/s11033-013-2783-0.
  55. T. Kolomin, M. Shadrina, M. Morozova, A. Volkova, L. Andreeva, P. Slominsky, S. Limborska, N. Myasoedov, The temporary dynamics of inflammation-related genes expression under tuftsin analog Selank action, Molecular Immunology 2014 Mar;58(1):50-5. doi: 10.1016/j.molimm.2013.11.002. Epub 2013 Nov 27.
  56. Khrunin AV, Khokhrin DV, Filippova IN, Esko T, Nelis M, Bebyakova NA, Bolotova NL, Klovins J, Nikitina-Zake L, Rehnström K, Ripatti S, Schreiber S, Franke A, Macek M, Krulišová V, Lubinski J, Metspalu A, Limborska SA. A genome-wide analysis of populations from European Russia reveals a new pole of genetic diversity in northern Europe. PLoS One. 2013;8(3):e58552. doi: 10.1371/journal.pone.0058552.
  57. Esko T, Mezzavilla M, Nelis M, Borel C, Debniak T, Jakkula E, Julia A, Karachanak S, Khrunin A, Kisfali P, Krulisova V, Aušrelé Kučinskiené Z, Rehnström K, Traglia M, Nikitina-Zake L, Zimprich F, Antonarakis SE, Estivill X, Glavač D, Gut I, Klovins J, Krawczak M, Kučinskas V, Lathrop M, Macek M, Marsal S, Meitinger T, Melegh B, Limborska S, Lubinski J, Paolotie A, Schreiber S, Toncheva D,Toniolo D, Wichmann HE, Zimprich A, Metspalu M, Gasparini P, Metspalu A, D'Adamo P. Genetic characterization of northeastern Italian population isolates in the context of broader European genetic diversity. Eur J Hum Genet. 2013 Jun;21(6):659-65. doi: 10.1038/ejhg.2012.229
  58. Alieva AKh, Filatova EV, Karabanov AV, Illarioshkin SN, Limborska SA, Shadrina M.I., Slominsky PA. miRNA expression is highly sensitive to a drug therapy in Parkinson's disease. Parkinsonism & Related Disorders 2014, DOI: 10.1016/j.parkreldis.2014.10.018
  59. Gusev A, …; Khrunin, A; … ; Limborska, S; …Slominsky, P…:, Stahl E; Partitioning heritability of regulatory and cell-type-specific variants across 11 common diseases. Am J Hum Genet. 2014;95(5):535-52. doi: 10.1016/j.ajhg.2014.10.004.
  60. Ripke, S; …; Khrunin, A; … ; Limborska, S; …Slominsky, P…: O'Donovan, MC. Biological insights from 108 schizophrenia-associated genetic loci. Nature, 2014. Volume: 511, Issue: 7510, Pages: 421-427.
  61. Medvedeva EV, Dmitrieva VG, Povarova OV, Limborska SA, Skvortsova VI, Myasoedov NF, Dergunova LV. The peptide semax affects the expression of genes related to the immune and vascular systems in rat brain focal ischemia: genome-wide transcriptional analysis. BMC Genomics. 2014 Mar 24;15(1):228. doi: 10.1186/1471-2164-15-228.
  62. Anelya Kh. Alieva, Maria I. Shadrina, Elena V. Filatova, Aleksey V. Karabanov, Sergey N. Illarioshkin, Svetlana A. Limborska, and Petr A. Slominsky. «Involvement of Endocytosis and Alternative Splicing in the Formation of the Pathological Process in the Early Stages of Parkinson’s Disease» BioMed Research International, vol. 2014, Article ID 718732, 6 pages, 2014. doi:10.1155/2014/718732
  63. Khrunin AV, Khokhrin DV, Moisseev AA, Gorbunova VA, Limborska SA. Pharmacogenomic assessment of cisplatin-based chemotherapy outcomes in ovarian cancer. Pharmacogenomics. 2014 Feb;15(3):329-37. doi: 10.2217/pgs.13.237.
  64. Filippenkov IB, Sudarkina OY, Limborska SA, Dergunova LV. Circular RNA of the human sphingomyelin synthase 1 gene: Multiple splice variants, evolutionary conservatism and expression in different tissues. RNA Biol. 2015 Aug 14:0. [Epub ahead of print]
  65. Sudarkina OY, Filippenkov IB, Brodsky IB, Limborska SA, Dergunova LV. Comparative analysis of sphingomyelin synthase 1 gene expression at the transcriptional and translational levels in human tissues. Mol Cell Biochem. 2015 Aug;406(1-2):91-9. doi: 10.1007/s11010-015-2427-x.
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