Klenov Mikhail Sergeevich | Institute of Molecular Genetics
Academic degree:
Doctor of Philosophy (Biology)

Academic title:
without academic rank


Division of IMG:
Laboratory of biochemical genetics of animals

Position:
Senior Researcher


Telephone:
+7-499-196-00-12

Е-mail:
klenov@img.ras.ru



Main research interests

Studies of silencing of transposable elements by short Piwi-interacting RNAs (piRNAs). Investigation of chromatin structure and functions of chromatin proteins in the germline and stem cells.
Investigation of natural RNA interference-like mechanism involved in regulation of Stellate genes in fruit fly Drosophila.


Teaching activities

Supervisor of 2 PhD thesis


Awards, achievements, memberships

2012 – Medal of Russian Academy of Sciences and Prize for Young Scientists
2008 – Academia Europaea prize for young Russian scientists
2008 – Prize of the Russian Science Support Foundation in the nomination "Best scientists with candidate degree"


Publications

  1. Klenov MS, Lavrov SA, Korbut AP, Stolyarenko AD, Yakushev EY, Reuter M, Pillai RS, Gvozdev VA. (2014) Impact of nuclear Piwi elimination on chromatin state in Drosophila melanogaster ovaries. Nucleic Acids Res. 42(10):6208-18.
  2. Mikhaleva EA, Yakushev EIu, Stoliarenko AD, Klenov MS, Pozovskiĭ IaM, Gvozdev VA. (2015) PIWI protein as a nucleolus visitor in Drosophila melanogaster. Mol Biol (Mosk). 49(1):184-9.
  3. Gvozdev VA, Stolyarenko AD, Klenov MS. (2015) Functions of piRNAs and the Piwi Protein in Drosophila. Genetika. 51(4):430-42.
  4. Yakushev EY, Sokolova OA, Gvozdev VA, Klenov MS. (2013) Multifunctionality of PIWI proteins in control of germline stem cell fate. Biochemistry (Mosc). 78(6):585-91.
  5. Klenov M.S., Sokolova O.A., Yakushev E.Y., Stolyarenko A.D., Mikhaleva E.A., Lavrov S.A., Gvozdev V.A., (2011) Separation of stem cell maintenance and transposon silencing functions of Piwi protein. Proc Natl Acad Sci U S A., 108(46), 18760-5.
  6. Sokolova OA, Yakushev EIu, Stolyarenko AD, Mikhaleva EA, Gvozdev VA, Klenov MS. (2011) The interplay of transposon silencing genes in the Drosophila melanogaster germline. Mol Biol (Mosk). 45(4):633-41.
  7. Kotelnikov R.N., Klenov M.S., Rozovsky Y.M., Olenina L.V., Kibanov M.V., Gvozdev V.A. (2009) Peculiarities of piRNA-mediated posttranscriptional silencing of Stellate repeats in testes of Drosophila melanogaster. Nucleic Acids Research, 37(10):3254-63.
  8. Klenov M.S., Lavrov S.A., Stolyarenko A.D., Ryazansky S.S., Aravin A.A., Tuschl T., Gvozdev V.A. (2007) Repeat-associated siRNAs cause chromatin silencing of retrotransposons in the Drosophila melanogaster germline. Nucleic Acids Research, 35(16):5430-8.
  9. Shpiz S, Kwon D, Uneva A, Kim M, Klenov M, Rozovsky Y, Georgiev P, Savitsky M, Kalmykova A. (2007) Characterization of Drosophila telomeric retroelement TAHRE: transcription, transpositions, and RNAi-based regulation of expression. Molecular Biology and Evolution, 24(11):2535-2545.
  10. Klenov MS, Stolyarenko AD, Riazanskiĭ SS, Sokolova OA, Konstantinov IN, Gvozdev VA. (2007) Role of short RNAs in regulating the expression of genes and mobile elements in germ cells. Ontogenez. 38(3):213-27.
  11. Kalmykova A.I., Klenov M.S., Gvozdev V.A. (2005) Argonaute protein PIWI controls mobilization of retrotransposons in the Drosophila male germline. Nucleic Acids Research, 33, 2052-2059.
  12. Klenov, M.S., Gvozdev, V.A. (2005). Heterochromatin formation: role of short RNAs and DNA methylation. Biochemistry (Mosc). 11, 1187-98.
  13. Aravin A.A., Klenov M.S., Vagin V.V., Bantignies F., Cavalli G., Gvozdev V.A. (2004) Dissection of a natural RNA silencing process in the Drosophila melanogaster germ line. Molecular and Cellular Biology, 24, 6742-6750.
  14. Vagin V.V., Klenov M.S., Kalmykova A.I., Stolyarenko A.D., Kotelnikov R.N., Gvozdev, V.A. (2004) The RNA interference proteins and vasa locus are involved in the silencing of retrotransposons in the female germline of Drosophila melanogaster. RNA biology, 1, 51-55.
  15. Gvozdev V., Aravin A., Abramov Y., Klenov M., Kogan G., Lavrov S., Naumova N., Olenkina O., Tulin A., Vagin V. (2003) Stellate repeats: targets of silencing and modules of repeat induced cis-inactivation and trans-activation. Genetica, 117(2-3), 239-245.
  16. A.A. Aravin, V.V. Vagin, N.M. Naumova, Ya. M. Rozovskii, M.S. Klenov, V.A.  Gvozdev. (2002). The phenomenon of RNA interference and development of organism. Ontogenez (Rus) v.33, №5, 349-360.
  17. A.A. Aravin, M.S. Klenov, V.V. Vagin, Ya. M. Rozovskii, and V.A. Gvozdev. (2002). Role of double-stranded RNA in eukaryotic gene silencing. Mol Biol (Mosk)., v. 36,  № 2, 240-251.