Gvozdev Vladimir Alekseevich | Institute of Molecular Genetics

Gvozdev Vladimir Alekseevich

Academic degree:
Doctor of Biological Sciences

Academic title:
Academician


Division of IMG:
Laboratory of biochemical genetics of animals

Position:
Head of Department


Telephone:
+7-499-196-00-12

Е-mail:
gvozdev@img.ras.ru

Resume (CV):
Microsoft Office document icon gvozdevvladimir.doc



Main research interests

Studies on gene expression regulation in eukaryotes are published in more than 150 papers.
1997—2005. Studies of gene expression restricted by small RNAs (piRNAs) using RNA interference principle.
2006—2015. Studies of piRNA systems involved in genome functioning. Studies of epigenetics of gene inactivation process caused by chromosomal rearrangements. Detection of novel genes encoding tissue specific translation related proteins.


Teaching activities

1985– present: Prof., Department of Molecular Biology, Lomonosov Moscow State University
Head of more than 30 Ph.D thesis


Awards, achievements, memberships

1983 -  USSR State Prize
2002 – Russian Federation State Prize
2006 — academician, Russian Academy of Sciences
Member of editorial boards of Russian Journals: “Genetics”, Моscow; “Biochemistry”, Моscow; “Моlecular Biology”, Моscow. 


Publications

  1. Aravin A.A., Naumova N.M., Tulin A.V., Vagin V.V, Rozovsky Ya.M., Gvozdev V.A.. (2001) Double stranded RNA-mediated silencing of genomic tandem repeats and transposable elements in Drosophila melanogaster germline. Current Biology, v. 11, 1017-1027, 2001
  2. Aravin A.A., Klenov M.S.,Vagin V.V.,Bantignies F.,Cavalli G.,Gvozdev V.A. Dissection of a natural RNA silencing process in the Drosophila melanogaster germline. Mol Cell Biol., 2004, 24, 6742-6750.
  3. Kalmykova AI, Klenov MS, Gvozdev VA. Argonaute protein PIWI controls mobilization of retrotransposons in the Drosophila male germline.  Nucleic Acids Res 2005, 33: 2052-2059.
  4. Usakin LA, Kogan GL, Kalmykova AI, Gvozdev VA. An alien promoter capture as a primary step of the evolution of testes expressed repeats in Drosophila melanogaster genome. Mol.Biol. Evol., 2005, 22:1555-1560.
  5. Abramov YA, Kogan GL, Tolchkov EV, Rasheva VI, Lavrov SA, Bonaccorsi S,    Kramerova IA, Gvozdev VA. Eu-heterochromatic rearrangements induce replication of heterochromatic sequences normally underreplicated in polytene chromosomes of Drosophila melanogaster. Genetics 2005, 171:1673-1681.
  6. Vagin V.V., Klenov M S., Kalmykova A.I, Stolyarenko A.D., Kotelnikov R  Gvozdev V.A. The RNA interference proteins and vasa locus are involved in the silencing of retrotransposons in the female germline of Drosophila melanogaster  RNA Biology, 2004, .1: 54-58.       
  7. Savitsky M., Kwon D., Georgiev P., Kalmykova A., Gvozdev V.  Telomere elongation is  under the control of the RNA-based mechanism in the Drosophila germline. Genes and Development, 2006, 20:345-354.
  8. Vasily V. Vagin, Alla Sigova, Chengjian Li, Herve Seitz, Vladimir Gvozdev, Phillip D.   Zamore A distinct small RNA Pathway silences selfish genetic elements in the germline. Science, 2006, 313:320-324.
  9. Klenov MS, Lavrov SA, Stolyarenko AD, Ryazansky  SS. ,Aravin AA, Tuschl  T,.    Gvozdev      VA. Repeat-associated siRNAs cause chromatin silencing of retrotransposons in the Drosophila melanogaster germline. Nucl Acids Res.  2007, 35:5430-5438.
  10. Egorova KS, Olenkina OM, Kibanov MV, Kalmykova AI, Gvozdev VA, Olenina LV.  Genetically derepressed nucleoplasmic Stellate protein in spermatocytes of  D.melanogaster interacts   with the catalytic subunit of protein kinase 2 and carries histone-like methylated mark.   J Mol Biol. 2009. 389(5):895-906.  
  11. Kotelnikov RN, Klenov MS, Rozovsky YM, Olenina LV, Kibanov MV, Gvozdev VA. Peculiarities of RNA-mediated post-transcriptional silencing of Stellate repeats in testes of Drosophila melanogaster. Nucleic Acids Res. 2009,37:3254-63
  12. Kibanov M.V., Egorova K.S., Ryazansky S.S.,Sokolova O.A., Kotov A.A., Olenkina O.M., Stolyarenko A.D., Gvozdev V.A. , Olenina L.V. A novel organelle, the piNG-body, in the nuage of Drosophila male germ cells is associated with piRNA-mediated gene silencing. Molecular Biology of the Cell, 22, 3410-3419, 2011.
  13. Ryasansky S.S., Gvozdev V.A., Berezikov E. Evidence of post-transcriptional regulation of  clustered microRNAs in Drosophila. BMC Genomics, 12: 371, 2011.
  14. Klenov M.S., Sokolova O.A., Yakushev E.Yu,, Stolyarenko A.D., Mikhaleva E.A., Lavrov S.A., Gvozdev V.A. Separation of stem cell maintenance and transposon silencing functions of the Piwi protein. Proc.Natl. Acad.Sci 108: 18760-18765. 2011. 
  15. Оlenkina O.M., Egorova K. S., Kibanov M.V., Gervaziev Y.V., Gvozdev V.A., Olenina L.V.    Promoter contribution of the testis-specific expression of Stellate gene family in Drosophila melanogaster. Gene, 499: 143-153, 2012.
  16.  Kogan G.L.,  Usakin L.A. , Ryazansky S.S., Gvozdev V.A. Expansion and Evolution of the X- linked testis specific multigene families in the melanogaster species subgroup. PLoS One 7, e37738, 2012.
  17.  Klenov M.S. Lavrov SA, Korbut AV, Stolyarenko AD, Yakushev, EYu, Reuter M,  Pillai R, Gvozdev VA. Impact of nuclear Piwi elimination on chromatin state in Drosophila melanogater ovaries. Nucl Acids Res 42: 6208-6218, 2014.