Akulenko Natalia Victorovna | Institute of Molecular Genetics
Academic degree:
Doctor of Philosophy (Biology)

Academic title:
without academic rank


Division of IMG:
Laboratory of research of genomic repeats in eukaryotes

Position:
Senior Researcher


Telephone:
+7-499-196-00-19

Е-mail:
n.akulenko11@gmail.com



Main research interests

1999 – 2006 – Identification of novel site-specific endonucleases encoded by T5-like bacteriophages. Study of their biochemical properties and mechanisms of the DNA-substrate recognition.
2007 – 2011 – Mechanisms of the transcription regulation in the process of development of Escherichia coli и Pseudomonas bacteriophages.
2012 – present time – The regulation of transposable elements expression by piRNA (PIWI interacting RNA) in Drosophila germ line.



Awards, achievements, memberships

1) G.K. Skryabin award for young scientists in molecular biology, 2002.
2) Grant of the President of the Russian Federation for support of young scientists (2008-2009).
3) Award of the charitable foundation "Future of Molecular Genetics" (2008-2010).
4) Metchnikov postdoctoral fellowship, award of the France embassy in Moscow, 2014.



Publications

  1. Telomeric repeat silencing in germ cells is essential for early development in Drosophila. Morgunova V, Akulenko N, Radion E, Olovnikov I, Abramov Y, Olenina LV, Shpiz S, Kopytova DV, Georgieva SG, Kalmykova A. Nucleic Acids Res. 2015 Aug 3. pii: gkv775.
  2. Testis-expressed cluster of microRNAs 959-964 controls spermatid differentiation in Drosophila. Ryazansky, S., Mikhaleva, E., Akulenko, N., Olenkina, O. bioRxiv. Cold Spring Harbor Labs Journals. 2014 doi:10.1101/013243
  3. DEAD-Box RNA helicases in animal gametogenesis. A. A. Kotov, N. V. Akulenko, M. V. Kibanov, and L. V. Olenina. Mol Biol (Mosk). 2014, 48, 1: 16-28.
  4. Genomic analysis of Pseudomonas putida phage tf with localized single-strand DNA interruptions. Glukhov AS, Krutilina AI, Shlyapnikov MG, Severinov K, Lavysh D, Kochetkov VV, McGrath JW, de Leeuwe C, Shaburova OV, Krylov VN, Akulenko NV, Kulakov LA. PLoS One. 2012;7(12):e51163.
  5.  Host RNA polymerase inhibitors encoded by ϕKMV-like phages of Pseudomonas. Klimuk E, Akulenko N, Makarova KS, Ceyssens PJ, Volchenkov I, Lavigne R, Severinov K. Virology. 2013 Feb 5;436(1): 67-74.
  6. Temporal regulation of gene expression of the Escherichia coli bacteriophage phiEco32. Pavlova O, Lavysh D, Klimuk E, Djordjevic M, Ravcheev DA, Gelfand MS, Severinov K, Akulenko N. J Mol Biol. 2012 Feb 24;416(3):389-99.
  7. Reprint of: inhibition of Escherichia coli RNAp by T7 Gp2 protein: role of negatively charged strip of amino acid residues in Gp2. Sheppard C, Cámara B, Shadrin A, Akulenko N, Liu M, Baldwin G, Severinov K, Cota E, Matthews S, Wigneshweraraj SR. J Mol Biol. 2011 Oct 7;412(5):832832-41.
  8. Inhibition of Escherichia coli RNAp by T7 Gp2 protein: role of negatively charged strip of amino acid residues in Gp2. Sheppard C, Cámara B, Shadrin A, Akulenko N, Liu M, Baldwin G, Severinov K, Cota E, Matthews S, Wigneshweraraj SR. J Mol Biol. 2011 Apr 15;407(5):623-32.
  9. Genomic and proteomic analysis of phiEco32, a novel Escherichia coli bacteriophage. Savalia D, Westblade LF, Goel M, Florens L, Kemp P, Akulenko N, Pavlova O, Padovan JC, Chait BT, Washburn MP, Ackermann HW, Mushegian A, Gabisonia T, Molineux I, Severinov K. J Mol Biol. 2008 Mar 28;377(3):774-89.
  10. Novel site-specific endonucleases F-TflI, F-TflII and F-TflIV encoded by the bacteriophage T5. Akulenko NV, Ivashina TV, Shaloĭko LA, Shliapnikov MG, Ksenzenko VN. Mol Biol (Mosk). 2004 Jul-Aug; 38(4):632-41.
  11. Structural and functional analysis of the phosphonoacetate hydrolase (phnA) gene region in Pseudomonas fluorescens 23F. Kulakova AN, Kulakov LA, Akulenko NV, Ksenzenko VN, Hamilton JT, Quinn JP. J Bacteriol. 2001 Jun;183(11):3268-75.