Shevelyov Yuri Yasenovich | Institute of Molecular Genetics

Shevelyov Yuri Yasenovich

Academic degree:
Doctor of Philosophy (Biology)

Academic title:
without academic rank

Division of IMG:
Laboratory of analysis of gene regulation

Head of Laboratory


Resume (CV):

Main research interests

Tissue-specific gene clusters are the universal type of gene organization in Drosophila (Boutanaev et al. 2002; Shevelyov et al. 2009).
Transcription of tissue-specific gene clusters are coordinately regulated at chromatin level (Kalmykova et al. 2005).
Silent tissue-specific gene clusters are additionally repressed by the contacts with nuclear lamina (Shevelyov et al. 2009).
Disruption of nuclear lamina results in the removal of loci from nuclear envelope (Shevelyov et al. 2009; Shevelyov and Nurminsky 2012).
Histone deacetylase HDAC3, but not the HDAC1 determines the positioning of tissue-specific gene clusters at nuclear lamina (Milon et al. 2012);
Chromatin is partitioned into active and inactive topologically associating domains (TADs) in Drosophila nucleus due to ability of “inactive” nucleosomes to interact with each other (Ulianov et al. 2016; Gavrilov et al. 2016);
In Drosophila ovarian somatic cells, the key effector protein of piRNA silencing system Piwi interacts with chromatin at nuclear pores and promiscuously binds numerous nuclear transcripts from genes and transposable elements (Ilyin et al. 2017).

Teaching activities

Lectures for students from Russian Chemico-Technological University named after D.I.Mendeleev at IMG RAS center for education and science “Genomics, molecular biotechnology and medicine”. 


  1. Shevelyov Y.Y., Balakireva M.D., Gvozdev V.A. (1989) Heterochromatic regions in different Drosophila melanogaster stocks contain similar arrangements of moderate repeats with inserted copia-like elements (mdg1). Chromosoma 98:117-122.
  2. Balakireva M.D., Shevelyov Y.Y., Nurminsky D.I., Gvozdev V.A., Livak K.J. (1992) Structural organization and diversification of Y-linked sequences comprising Su(Ste) genes in Drosophila melanogaster. Nucleic Acids Res. 20:3731-3736.
  3. Shevelyov Y.Y. (1992) Copies of a Stellate gene variant are located in the X heterochromatin of Drosophila melanogaster and are probably expressed. Genetics 132:1033-1037.
  4. Shevelyov Y.Y. (1993) Aurora, a non-mobile retrotransposon in Drosophila  melanogaster heterochromatin. Mol. Gen. Genet. 239:205-208.
  5. Nurminsky D.I., Shevelyov Y.Y., Nuzhdin S.V., Gvozdev V.A. (1994) Structure, molecular evolution and maintenance of copy number of extended repeated structures in the X-heterochromatin of Drosophila melanogaster. Chromosoma 103:277-285.
  6. Kalmykova A.I., Shevelyov Y.Y., Dobritsa A.A., Gvozdev V.A. (1997) Acquisition and amplification of a testis-expressed autosomal gene, SSL, by the Drosophila Y chromosome. Proc. Natl. Acad. Sci. USA 94:6297-6302.
  7. Nurminsky D.I., Nurminskaya M.V., Benevolenskaya E.V., Shevelyov Y.Y., Hartl D.L., Gvozdev V.A. (1998) Cytoplasmic dynein intermediate-chain isoforms with different targeting properties created by tissue-specific alternative splicing. Mol. Cell. Biol. 18:6816-6825.
  8. Gvozdev V.A., Kogan G.L., Tulin A.A., Aravin A.A., Naumova N.M., Shevelyov Y.Y. (2000) Paralogous Stellate and Su(Ste) repeats: evolution and ability to silence a reporter gene. Genetica, 109:131-140.
  9. Kalmykova A.I., Shevelyov Y.Y., Polesskaya O.O., Dobritsa A.A., Evstafieva A.G., Boldyreff B., Issinger O.-G., Gvozdev V.A. (2002). CK2βtes gene encodes a testis-specific isoform of the regulatory subunit of casein kinase 2 in Drosophila melanogaster. Eur. J. Biochem. 269:1418-1427.
  10. Boutanaev A.M., Kalmykova A.I., Shevelyov Y.Y., Nurminsky D.I. (2002). Large clusters of co-expressed genes in the Drosophila genome. Nature 420:666-669.
  11. Kalmykova A.I., Nurminsky D.I., Ryzhov D.V., Shevelyov Y.Y. (2005) Regulated chromatin domain comprising cluster of co-expressed genes in Drosophila melanogaster. Nucleic Acids Res. 33:1435-1444.
  12. Shevelyov Y.Y., Lavrov S.A., Mikhaylova L.M., Nurminsky I.D., Kulathinal R.J., Egorova K.S., Rozovsky Y.M., Nurminsky D.I. (2009) The B-type lamin is required for somatic repression of testis-specific gene clusters. Proc. Natl. Acad. Sci. USA 106:3282-3287.
  13. Shevelyov Y.Y., Nurminsky D.I. (2012) The nuclear lamina as a gene-silencing hub. Curr. Issues Mol. Biol. 14:27-38.
  14. Milon B.C., Cheng H., Tselebrovsky M.V., Lavrov S.A., Nenasheva V.V., Mikhaleva E.A., Shevelyov Y.Y., Nurminsky D.I. (2012) Role of histone deacetylases in gene regulation at nuclear lamina. PLoS One 7:e49692.
  15. Ulianov S.V., Khrameeva E.E., Gavrilov A.A., Flyamer I.M., Kos P., Mikhaleva E.A., Penin A.A., Logacheva M.D., Imakaev M.V., Chertovich A., Gelfand M.S., Shevelyov Y.Y., Razin S.V. (2016) Active chromatin and transcription play a key role in chromosome partitioning into topologically associating domains. Genome Res. 26:70-84.
  16. Gavrilov A.A., Shevelyov Y.Y., Ulianov S.V., Khrameeva E.E., Kos P., Chertovich A., Razin S.V. (2016) Unraveling the mechanisms of chromatin fibril packaging. Nucleus 7:319-324.
  17. Ulianov S.V., Shevelyov Y.Y., Razin S.V. (2016) Lamina-associated chromatin in the context of the mammalian genome folding. Biopolymers Cell 32:327-333.
  18. Ilyin A.A., Ryazansky S.S., Doronin S.A., Olenkina O.M., Mikhaleva E.A., Yakushev E.Y., Abramov Y.A., Belyakin S.N., Ivankin A.V., Pindyurin A.V., Gvozdev V.A., Klenov M.S., Shevelyov Y.Y. (2017) Piwi interacts with chromatin at nuclear pores and promiscuously binds nuclear transcripts in Drosophila ovarian somatic cells. Nucleic Acids Res. 45:7666-7680.