Lipasova Valentina Aleksandrovna | Institute of Molecular Genetics
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Academic degree:
without a degree
Academic title:
without academic rank
Division of IMG:
Laboratory regulation of gene expression of microorganisms
Position:
Junior Researcher
Telephone:
+7-499-196-02-15
Е-mail: |
Main research interests
Major investigations are devoted to study of Quorum Sensing (QS) regulation and its role in the control of cell processes, investigations of enterobacteria antibiotics microcins, analysis of the action of volatile organic compounds (VOCs).
1990 - 2006. Investigations of the ability of enterobacteria from various sources to synthesize microcins were performed, types of microcins were determined, it was shown that their synthesis is connected with plasmids. The work was carried out on the development and introduction in practice of probiotic Romakol preparation (obtained on the basis of the strain Escherichia coli, synthesizing microcin) for the prevention and treatment of intestinal diseases of farm animals. Microcins of B-type and genetic control of their synthesis were studied.
2003 - at recent time. Investigations of Quorum Sensing systems of regulation of Pseudomonas chlororaphis and Burkholderia cenocepacia. Obtaining the mutants of B. cenocepacia with changed synthesis of the signal molecules of QS regulation N-acyl-homoserine lactones.
2011 - at recent time. Study of the volatile organic compounds (VOC) synthesis by soil and rhizosphere bacteria Pseudomonas и Serratia.
1990 - 2006. Investigations of the ability of enterobacteria from various sources to synthesize microcins were performed, types of microcins were determined, it was shown that their synthesis is connected with plasmids. The work was carried out on the development and introduction in practice of probiotic Romakol preparation (obtained on the basis of the strain Escherichia coli, synthesizing microcin) for the prevention and treatment of intestinal diseases of farm animals. Microcins of B-type and genetic control of their synthesis were studied.
2003 - at recent time. Investigations of Quorum Sensing systems of regulation of Pseudomonas chlororaphis and Burkholderia cenocepacia. Obtaining the mutants of B. cenocepacia with changed synthesis of the signal molecules of QS regulation N-acyl-homoserine lactones.
2011 - at recent time. Study of the volatile organic compounds (VOC) synthesis by soil and rhizosphere bacteria Pseudomonas и Serratia.
Publications
The total number of published articles - 49.
- И.А. Хмель, А.З. Метлицкая, Д.Э. Фоменко, Г.С. Катруха, Е.И. Басюк, Н.Е. Курепина, В.А. Липасова, В.М. Безруков. Микроцины – новые пептидные антибиотики энтеробактерий и генетический контроль их синтеза. Молекулярная биология, 1999, т. 33, 113-119.
- Хмель И.А., Веселова М.А., Метлицкая А.З., Клейн Ш., Липасова В.А., Маяцкая А.В., Чернин Л.С. Синтез сигнальных ацил-гомосерин-лактонов, участвующих в межклеточном обмене информацией, у ризосферных и почвенных бактерий Pseudomonas и Xanthomonas. Генетика, 2002, т. 38, с. 568-570.
- Veselova M., Kholmeckaya M., Klein S., Voronina E., Lipasova V., Metlitskaya A., Mayatskaya A., Lobanok E., Khmel I., Chernin L. Production of N- acylhomoserine lactone signal molecules by Gram-negative soil-borne and plant- associated bacteria. Folia Microbiol. 2003, v. 48 N6, 794-798.
- Шедова Е.Н., Березина О.В., Хмель И.А., Липасова В.А., Боррисс Р., Великодворская Г.А. Выделение, характеристика и клонирование генов бактериальных фитаз. Молек. генетика, микробиол. и вирусол., 2004, N1, 17-21.
- Khmel I.A., Ovadis M.I., Mayatskaya A.V., Veselovskii A.M., Bass I.A., Lipasova V.A., Bolshoy A., Chet I., Chernin L.S. Activity of Serratia plymuthica IC1270 gene chiA promoter region in Escherichia coli mutants deficient in global regulators of transcription. J. Basic Microbiol. 2005, v. 45, 426-437.
- Веселова М.А., Липасова В.А., Астаурова О.Б., Атамова Э.Э., Проценко М.А., Буза Н.Л., Метлицкая А.З., Данилова Н.Н., Чернин Л.С., Хмель И.А. Quorum Sensing регуляция у почвенных псевдомонад. Микробиология, 2006, Т. 75, 465-468.
- Липасова В.А., Волошина П.В., Данилова Н.Н., Чернин Л.С., Хмель И.А. Влияние мутаций в генах глобальных регуляторов grrS и rpoS на синтез фосфатаз у Serratia plymuthica // Генетика, 2007. Т. 43. С. 1700-1703.
- Веселова М.А.. Клейн Ш., Басс И.А.. Липасова В.А.. Метлицкая А.З.. Овадис М.И., Чернин Л.С.. Хмель И.А. Quorum Sensing системы регуляции, синтез феназиновых антибиотиков и фунгицидная активность у ризосферного штамма Pseudomonas chlororaphis 449. Генетика 2008, 44, 1617-1626.
- Shedova E., Lipasova V., Velikodvorskaya G., Ovadis M., Chernin L., Khmel I. Phytase activity and its regulation in a rhizospheric strain of Serratia plymuthica. Folia microbiologica. 2008, 53, 110-114.
- Липасова В.А., Атамова Э.Э., Хмель И.А. Синтез N-ацил-гомосеринлактонов, феназинов, некоторые ферментативные активности и фунгицидная активность в клетках Pseudomonas chlororaphis 449 с инактивированным геном rpoS. Молек. генетика, микробиология и вирусология, 2009, N 1, 8-11.
- Липасова В.А., Атамова Э.Э., Веселова М.А., Тарасова Н.Н., Хмель И.А. Экспрессия гена N-ацил-гомосерин лактоназы AiiA влияет на свойства ризосферного штамма Pseudomonas chlororaphis 449. Генетика, 2009, т. 45, 38-42.
- Веселова М.А.. Липасова В.А.. Овадис М.И., Чернин Л.С.. Хмель И.А. Структура и экспрессия гена vfr Pseudomonas chlororaphis 449. Генетика 2009, т. 45, 1203-1210.
- Veselova M., Lipasova V., Protsenko M.A., Buza N., Khmel I.A. GacS-Dependent regulation of enzymic and antifungal activities and synthesis of N-acylhomoserine lactones in rhizospheric strain Pseudomonas chlororaphis 449. Folia Microbiologica. 2009, v. 54, 401–408.
- Веселова М.А., Липасова В.А., Зайцева Ю.В., Кокшарова О.А., Чернуха Ю.М., Романова Ю.М., Хмель И.А. Мутанты Burkholderia cenocepacia с измененным синтезом N-ацил-гомосеринлактонов – сигнальных молекул Quorum Sensing регуляции. Генетика, 2012, т. 48, № 5, 608-616.
- Плюта В.А., Липасова В.А.. Кузнецов А.Е.. Хмель И.А. Действие салициловой, индолил-3-уксусной, гиббереллиновой и абсцизовой кислот на образование биопленок бактериями Agrobacterium tumefaciens C58 и Pseudomonas aeruginosa PAO1. Биотехнология, 2012, № 3, 53-58.
- M.A. Radzig, V.A. Nadtochenko, O.A. Koksharova , J. Kiwi, V.A. Lipasova , I.A. Khmel. Antibacterial effects of silver nanoparticles on Gram-negative bacteria: influence on the growth and biofilms formation, mechanisms of action. Colloids and Surfaces B: Biointerfaces, 2013, 102, 300-306
- Plyuta V.A., Lipasova V.A., Kuznetsov A.E., Khmel I.A. Effect of salicylic, indole-3-acetic, gibberellic, and abscisic acids on biofilm formation by Agrobacterium tumefaciens C58 and Pseudomonas aeruginosa PAO1. Applied Biochemistry and Microbiology, 2013, V. 49 N 8, P. 706-710..
- A. A. Popova, O. A. Koksharova, V. A. Lipasova, Ju. V. Zaitseva, O. A. Katkova-Zhukotskaya, S. Iu. Eremina, A. S. Mironov, L. S. Chernin, I. A. Khmel. Inhibitory and toxic Effects of Volatiles emitted by Strains of Pseudomonas and Serratia on Growth and Survival of selected Microorganisms, Caenorhabditis elegans and Drosophila melanogaster. BioMed Research International, Volume 2014, Article ID 125704, 11 pages, http://dx.doi.org/10.1155/2014/125704.