Lavrov Sergey Alexandrovich | Institute of Molecular Genetics

Lavrov Sergey Alexandrovich

Academic degree:
Doctor of Philosophy (Biology)

Academic title:
without academic rank

Division of IMG:
Laboratory of biochemical genetics of animals

Senior Researcher



Main research interests

The main field of studies is the interconnection of gene expression regulation and chromatin structure in the Drosophila model organism. There are also methodological publications related to chromatin immunoprecipitation technique and combined visualization of different types of molecules using fluorescent microscopy.
Results of the studies of mechanisms of Polycomb-mediated genes repression (2000-2004), links between piRNA system and chromatin structure (2005-2014) and peculiarities of heterochomatin position effect variegation (2006-current) are presented in the publications list below.

Teaching activities

Ph. D. thesis supervision


  1. Abramov, Y. A., G. L. Kogan, E. V. Tolchkov, V. I. Rasheva, S. A. Lavrov, S. Bonaccorsi, I. A. Kramerova and V. A. Gvozdev (2005). "Eu-heterochromatic rearrangements induce replication of heterochromatic sequences normally underreplicated in polytene chromosomes of Drosophila melanogaster." Genetics 171(4): 1673-1681.
  2. Alatortsev, V. E., I. A. Kramerova, M. V. Frolov, S. A. Lavrov and E. D. Westphal (1997). "Vinculin gene is non-essential in Drosophila melanogaster." FEBS Lett 413: 197-201.
  3. Bantignies, F., C. Grimaud, S. Lavrov, M. Gabut and G. Cavalli (2003). "Inheritance of Polycomb-dependent chromosomal interactions in Drosophila." Genes Dev 17(19): 2406-2420.
  4. Chanas, G., S. Lavrov, F. Iral, G. Cavalli and F. Maschat (2004). "Engrailed and polyhomeotic maintain posterior cell identity through cubitus-interruptus regulation." Dev Biol 272(2): 522-535.
  5. Comet, I., E. Savitskaya, B. Schuettengruber, N. Negre, S. Lavrov, A. Parshikov, F. Juge, E. Gracheva, P. Georgiev and G. Cavalli (2006). "PRE-mediated bypass of two Su(Hw) insulators targets PcG proteins to a downstream promoter." Dev Cell 11(1): 117-124.
  6. Gvozdev, V. A., A. A. Aravin, Y. A. Abramov, M. S. Klenov, G. L. Kogan, S. A. Lavrov, N. M. Naumova, O. M. Olenkina, A. V. Tulin and V. V. Vagin (2003). "Stellate repeats: targets of silencing and modules causing cis-inactivation and trans-activation." Genetica 117(2-3): 239-245.
  7. Klenov, M. S., S. A. Lavrov, A. P. Korbut, A. D. Stolyarenko, E. Y. Yakushev, M. Reuter, R. S. Pillai and V. A. Gvozdev (2014). "Impact of nuclear Piwi elimination on chromatin state in Drosophila melanogaster ovaries." Nucleic Acids Res 42(10): 6208-6218.
  8. Klenov, M. S., S. A. Lavrov, A. D. Stolyarenko, S. S. Ryazansky, A. A. Aravin, T. Tuschl and V. A. Gvozdev (2007). "Repeat-associated siRNAs cause chromatin silencing of retrotransposons in the Drosophila melanogaster germline." Nucleic Acids Res 35(16): 5430-5438.
  9. Klenov, M. S., O. A. Sokolova, E. Y. Yakushev, A. D. Stolyarenko, E. A. Mikhaleva, S. A. Lavrov and V. A. Gvozdev (2011). "Separation of stem cell maintenance and transposon silencing functions of Piwi protein." Proc Natl Acad Sci U S A 108(46): 18760-18765.
  10. Lavrov, S., J. Dejardin and G. Cavalli (2004). "Combined immunostaining and FISH analysis of polytene chromosomes." Methods Mol Biol 247: 289-303.
  11. Milon, B. C., H. Cheng, M. V. Tselebrovsky, S. A. Lavrov, V. V. Nenasheva, E. A. Mikhaleva, Y. Y. Shevelyov and D. I. Nurminsky (2012). "Role of histone deacetylases in gene regulation at nuclear lamina." PLoS One 7(11): e49692.
  12. Negre, N., J. Hennetin, L. V. Sun, S. Lavrov, M. Bellis, K. P. White and G. Cavalli (2006). "Chromosomal distribution of PcG proteins during Drosophila development." PLoS Biol 4(6): e170.
  13. Negre, N., S. Lavrov, J. Hennetin, M. Bellis and G. Cavalli (2006). "Mapping the Distribution of Chromatin Proteins by ChIP on Chip." Methods in Enzymology 410: 316-341.
  14. Olenkina, O. M., L. V. Olenina, S. A. Lavrov, M. S. Klenov and V. A. Gvozdev (2008). Analysis of testis-expressed Stellate genes promoter region in D. melanogaster. Фактори експериментальної еволюції організмів: Зб. наук. пр. Киев, ЛОГОС. 4: 352-357.
  15. Olovnikov, I., S. Ryazansky, S. Shpiz, S. Lavrov, Y. Abramov, C. Vaury, S. Jensen and A. Kalmykova (2013). "De novo piRNA cluster formation in the Drosophila germ line triggered by transgenes containing a transcribed transposon fragment." Nucleic Acids Res 41(11): 5757-5768.
  16. Shevelyov, Y. Y., S. A. Lavrov, L. M. Mikhaylova, I. D. Nurminsky, R. J. Kulathinal, K. S. Egorova, Y. M. Rozovsky and D. I. Nurminsky (2009). "The B-type lamin is required for somatic repression of testis-specific gene clusters." Proc Natl Acad Sci U S A 106(9): 3282-3287.
  17. Shpiz, S., S. Lavrov and A. Kalmykova (2014). "Combined RNA/DNA fluorescence in situ hybridization on whole-mount Drosophila ovaries." Methods Mol Biol 1093: 161-169.
  18. Shpiz, S., I. Olovnikov, A. Sergeeva, S. Lavrov, Y. Abramov, M. Savitsky and A. Kalmykova (2011). "Mechanism of the piRNA-mediated silencing of Drosophila telomeric retrotransposons." Nucleic Acids Res 39(20): 8703-8711.
  19. Tolchkov, E. V., I. A. Kramerova, S. A. Lavrov, V. I. Rasheva, S. Bonaccorsi, V. E. Alatortsev and V. A. Gvozdev (1997). "Position-effect variegation in Drosophila melanogaster X chromosome inversion with a breakpoint in a satellite block and its suppression in a secondary rearrangement." Chromosoma 106(8): 520-525.
  20. Abramov, Y. A., M. V. Kibanov, V. A. Gvozdev and S. A. Lavrov (2011). "Genetic and molecular analysis of gene trans-inactivation caused by homologous eu-heterochromatic chromosome rearrangement in Drosophila melanogaster." Dokl Biochem Biophys 437: 72-76.
  21. Erist, L. K., V. S. Kosorukov, T. A. Antipova, M. Chupina Iu, A. V. Tulin, S. A. Lavrov, V. N. Bashkirov, V. A. Gvozdev, G. Brem and L. I. Korochkin (1999). "[Preparation of transgenic house flies Musca domestica]." Dokl Akad Nauk 367(3): 430-432.
  22. Gvozdev, V. A., A. Abramov Iu, G. L. Kogan and S. A. Lavrov (2007). "[Distorted heterochromatin replication in Drosophila melanogaster polytene chromosomes as a result of euchromatin-heterochromatin rearrangements]." Genetika 43(1): 18-26.
  23. Gvozdev, V. A., V. E. Alatortsev, A. A. Aravin, A. I. Kalmykova, G. L. Kogan, S. A. Lavrov, N. M. Naumova, D. I. Nurminskii, V. I. Rasheva and E. V. Tolchkov (1999). "[Heterochromatin: molecular evolution and effects of gene location in Drosophila melanogaster]." Mol Biol (Mosk) 33(1): 14-25.
  24. Lavrov, S. A. and M. V. Kibanov (2007). "Noncoding RNAs and chromatin structure." Biochemistry (Mosc) 72(13): 1422-1438.
  25. Lavrov, S. A. and E. V. Mavrodiev (2003). "[Epigenetic inheritance and its possible role in the evolution of plant species]." Zh Obshch Biol 64(5): 403-420.
  26. Lavrov, S. A., A. S. Shatskikh, M. V. Kibanov and V. A. Gvozdev (2013). "[Correlation on a cellular level of gene transcriptional silencing and heterochromatin compartment dragging in case of PEV-producing eu-heterochromatin rearrangement in Drosophila melanogaster]." Mol Biol (Mosk) 47(2): 286-291.
  27. Lavrov, S. A., E. V. Tolchkov, I. A. Kramerova and V. A. Gvozdev (1998). "[Disruption of polytenization of DNA from the euchromatin region of the Drosophila melanogaster X-chromosome, caused by euheterochromatin restructuring]." Mol Biol (Mosk) 32(6): 992-997.
  28. Mavrodiev, E. V., S. A. Lavrov and V. A. Sagalaev (1997). ""The flora of Sarepta" database." Botanical jornal (Botanicheskii zhurnal. Rus) 82(2): 86-90.