Kuzmenko Anton Viktorovich | Institute of Molecular Genetics
Academic degree:
Doctor of Philosophy (Biology)

Academic title:
without academic rank


Division of IMG:
Laboratory of RNA biology and epigenetics

Position:
Researcher


Telephone:
+7-499-196-00-15

Е-mail:
dr.ant.kuz@gmail.com



Main research interests

The main works are devoted to the study of mitochondrial translation on the model system of budding yeast Saccharomyces cerevisiae.

2010-2011. A study of the diffusion characteristics of the main channel-forming protein of the polypeptide import complex in the outer mitochondrial membrane (Tom40p) by the SPT microscopy (Single Particle Tracking Microscopy).

2011-2017. A series of works in which S. cerevisiae mitochondrial translation initiation factor 3 (the protein Aim23p) was first discovered and characterized. It has been experimentally shown that Aim23p is not a classical translation initiation factor, and acts as an activator for a number of mitochondrial RNAs, and also appears to be involved in the coordination of complex V assembly of the electron transport chain.



Teaching activities

2010 - present: Junior Researcher, Department of Molecular Biology, Biological Faculty, M.V. Lomonosov Moscow State University.
Supervisor of 2 bachelor's theses.



Awards, achievements, memberships

M.V.Lomonosov Moscow State University stipend for young teachers and scientists (Russia, 2015)
O.V.Deripaska award for talented students, graduate students and young scientist of Moscow State University (Russia, 2013)



Publications

  1. Kuzmenko, A., Derbikova, K., Salvatori, R., Tankov, S., Atkinson, G. C., Tenson, T., Ott, M., Kamenski, P., and Hauryliuk, V. (2016) Aim-less translation: loss of Saccharomyces cerevisiae mitochondrial translation initiation factor mIF3/Aim23 leads to unbalanced protein synthesis. Scientific reports 6, 18749
  2. Kuzmenko, A., Derbikova, K., Hauryliuk, V., and Kamenski, P. (2015) Aim23 is an yeast mitochondrial translation initiation factor 3 which is unnecessary for protein synthesis. Yeast 32, S192-S193
  3. Kuzmenko, A., Atkinson, G. C., Levitskii, S., Zenkin, N., Tenson, T., Hauryliuk, V., and Kamenski, P. (2014) Mitochondrial translation initiation machinery: conservation and diversification. Biochimie 100, 132-140
  4. Atkinson, G. C., Kuzmenko, A., Chicherin, I., Soosaar, A., Tenson, T., Carr, M., Kamenski, P., and Hauryliuk, V. (2014) An evolutionary ratchet leading to loss of elongation factors in eukaryotes. BMC evolutionary biology 14, 35
  5. Kuzmenko, A. V., Levitskii, S. A., Vinogradova, E. N., Atkinson, G. C., Hauryliuk, V., Zenkin, N., and Kamenski, P. A. (2013) Protein biosynthesis in mitochondria. Biochemistry. Biokhimiia 78, 855-866
  6. Atkinson, G. C., Kuzmenko, A., Kamenski, P., Vysokikh, M. Y., Lakunina, V., Tankov, S., Smirnova, E., Soosaar, A., Tenson, T., and Hauryliuk, V. (2012) Evolutionary and genetic analyses of mitochondrial translation initiation factors identify the missing mitochondrial IF3 in S. cerevisiae. Nucleic acids research 40, 6122-6134
  7. Kuzmenko, A., Tankov, S., English, B. P., Tarassov, I., Tenson, T., Kamenski, P., Elf, J., and Hauryliuk, V. (2011) Single molecule tracking fluorescence microscopy in mitochondria reveals highly dynamic but confined movement of Tom40. Scientific reports 1, 195