Ilyin Artem Aleksandrovich | Institute of Molecular Genetics

Ilyin Artem Aleksandrovich

Academic degree:
without a degree

Academic title:
without academic rank


Division of IMG:
Laboratory of analysis of gene regulation

Position:
Junior Researcher


Telephone:
+74991960809

Е-mail:
ilyin@img.ras.ru



Main research interests

Mechanisms of action of small RNAs in eukaryotes. piRNA pathway. Suppression of transposable elements transcription. Regulation of gene expression. Mechanisms determining chromatine structure. Regulation of cell type-specific gene expression.
We determined and analyzed genomic binding sites of Piwi, HP1, Polycomb and lamin Dm0 proteins in different cell types of Drosophila (Ilyin et. al, 2017; Pindyurin et. al, 2018). We analyzed piRNA processing in flamKG/Df mutants and found the increasing non-specific piRNA production from the genic transcripts (Sokolova et. al, 2019).



Publications

  1. Sokolova OA, Ilyin AA, Poltavets AS, Nenasheva VV, Mikhaleva EA, Shevelyov YY, Klenov MS. Yb body assembly on the flamenco piRNA precursor transcripts reduces genic piRNA production.  Mol Biol Cell. 2019 Apr 3:mbcE17100591. doi: 10.1091/mbc.E17-10-0591
  2. Ulianov SV, Doronin SA, Khrameeva EE, Kos PI, Luzhin AV, Starikov SS, Galitsyna AA, Nenasheva VV, Ilyin AA, Flyamer IM, Mikhaleva EA, Logacheva MD, Gelfand MS, Chertovich AV, Gavrilov AA, Razin SV, Shevelyov YY. Nuclear lamina integrity is required for proper spatial organization of chromatin in Drosophila. Nat Commun. 2019 Mar 12;10(1):1176. doi: 10.1038/s41467-019-09185-y
  3. Pindyurin AV, Ilyin AA, Ivankin AV, Tselebrovsky MV, Nenasheva VV, Mikhaleva EA, Pagie L, van Steensel B, Shevelyov YY. The large fraction of heterochromatin in Drosophila neurons is bound by both B-type lamin and HP1a. Epigenetics Chromatin. 2018 Nov 1;11(1):65. doi: 10.1186/s13072-018-0235-8
  4. Ilyin AA, Ryazansky SS, Doronin SA, Olenkina OM, Mikhaleva EA, Yakushev EY, Abramov YA, Belyakin SN, Ivankin AV, Pindyurin AV, Gvozdev VA, Klenov MS, Shevelyov YY. Piwi interacts with chromatin at nuclear pores and promiscuously binds nuclear transcripts in Drosophila ovarian somatic cells. Nucleic Acids Res. 2017 Jul 27;45(13):7666-7680. doi: 10.1093/nar/gkx355