Filippenkov Ivan Borisovich | Institute of Molecular Genetics
Academic degree:
Doctor of Philosophy (Biology)

Academic title:
without academic rank


Division of IMG:
Laboratory of functional genomics

Position:
Senior Researcher


Telephone:
+7-499-196-18-58

Е-mail:
filippenkov@img.msk.ru



Main research interests

The main area of Ivan B. Filippenkov research is human molecular genetics, including transcriptomics, study of RNA biogenesis, pharmacogenomics and pharmacotranscriptomics.
Circular RNAs of sphingomyelin synthase gene have been found and studied in human and rodent tissues. The results were obtained on the features of the formation of the structure and expression of circular RNA in adult and embryonic tissues.
The analysis of the effect of the regulatory peptides on the transcriptome under the conditions of experimental cerebral ischemia was carried out. Signaling pathways and biological processes have been identified that are associated with the response of brain cells to the effect of peptides. The study revealed the neuroprotective properties of these peptides under ischemia conditions.
At present, studies of the role of noncoding RNAs under ischemia, stress-induced impairment of memory and behaviour, as well as under the action of regulatory peptides of various structures are ongoing.


Teaching activities

2018: Development of an educational course «Transcriptome Studies in Molecular Genetics», D. Mendeleev University of Chemical Technology of Russia.



Awards, achievements, memberships

Editorial activities:
2018: Member of the Editorial Board of the Journal of Bioinformatics and Genomics
 
Membership in scientific societies since:
2015: Member of European Society of Human Genetics (ESHG).
 
Award and prizes:
2012: Prize for the best poster presentation at the International Scientific and Practical Conference "Biotechnology: current state and future development. Pharmaceutical and medical biotechnologies” (March 20-22, 2012, Moscow, Russia);
2015: Prize for the best poster presentation at the Third Summer School on Bioinformatics (July 20-25, 2015, Moscow, Russia);
2016: Fellowship at the European Human Genetics Conference 2016 (May 21-24, 2016 Barcelona, Spain);
2017: Prize for the best poster presentation at the III National Congress on Regenerative Medicine (November 15-18, 2017, Moscow, Russia);
2018: Fellowship at the European Human Genetics Conference 2018 (June 16-19, 2018 Milan, Italy);
2018: Prize for the best poster presentation at the VIII International School of Young Scientists on Molecular Genetics "Genetic organization and molecular mechanisms of the functioning of living systems" (November 19 - 23, 2018, Zvenigorod, Moscow).
2019: Prize for the best poster presentation at the VI Congress of physiologists of CIS/ VI Congress of Biochemistry of Russia, Symposium «Proteins and Peptides», (Sochi, October 1–6, 2019)



Publications

Ivan B. Filippenkov is author of 22 articles, 1 monograph and more than 20 abstracts published in Peer-reviewed journals.
 
Publications since 2015:

  1. Filippenkov IB, Stavchansky VV, Denisova AE, Yuzhakov VV, Sevan'kaeva LE, Sudarkina OYu, Dmitrieva VG, Gubsky LV, Myasoedov NF, Limborska SA, Dergunova LV // Novel Insights into the Protective Properties of ACTH(4-7)PGP (Semax) Peptide at the Transcriptome Level Following Cerebral Ischaemia–Reperfusion in Rats // Genes 2020, 11(6), 681; https://doi.org/10.3390/genes11060681, Impact Factor 3.759
  2. Dergunova LV, Filippenkov IB, Limborska SA, Myasoedov NF // Pharmacotranscriptomics of peptide drugs with neuroprotective properties // Med Res Rev. 2020. doi: 10.1002/med.21704, Impact Factor 9.791
  3. Filippenkov IB, Dergunova LV, Limborska SA, MyasoedovNF // Neuroprotective Effects of Peptides in the Brain: Transcriptome Approach, Biochemistry (Moscow), 2020, Vol. 85, No. 3, pp. 279-287. DOI: 10.1134/S0006297920030037, Impact Factor 1.978.
  4. Filippenkov IB, Dergunova LV, Limborska SA // The Role of Noncoding RNAs in Brain Cells during Rat Cerebral Ischemia // 2020, Chapter in the book «Non-Coding RNAs» ISBN 978-1-78985-656-9, OpenIntech, DOI: http://dx.doi.org/10.5772/intechopen.88402
  5. Filippenkov IB, Dergunova LV. The role of coding and regulatory RNAs during acute stress. Molekulyarnaya Genetika, Mikrobiologiya i Virusologiya (Molecular Genetics, Microbiology and Virology). 2020;38(3):103–107. https://doi.org/10.17116/molgen202038031103
  6. Filippenkov I.B., Stavchansky V.V., Glazova N.Yu., Sebentsova E.A., Levitskaya N.G., Myasoedov N.F., Limborska S.A., Dergunova L.V. Genome-wide RNA sequencing as a method for assessing the effects of synthetic derivatives of melanocortin under normal conditions and under acute stress. Medical Genetics. 2020;19(5):101-102. https://doi.org/10.25557/2073-7998.2020.05.101-102)
  7. Khrunin A.V., Khvorykh G.V., Gnatko E.D., Filippenkov I.B., Stavchansky V.V., Dergunova L.V., Limborska S.A. Study of polymorphism of human genes, orthologues of which are functionally involved in the response to experimental brain ischemia in model systems. Medical Genetics. 2020;19(5):83-85, https://doi.org/10.25557/2073-7998.2020.05.83-85
  8. Nosova E.V., Filippenkov I.B., Rozhkova A.V., Dmitrieva V.G., Dergunov A.D., Limborska S.A., Dergunova L.V. Search for circular RNAs of the genes involved in lipid metabolism and atherogenesis. Medical Genetics. 2020;19(5):46-47. https://doi.org/10.25557/2073-7998.2020.05.46-47)
  9. Sudarkina O.Yu., Dmitrieva V.G., Filippenkov I.B., Stavchansky V.V., Denisova A.E., Gubsky L.V., Limborska S.A., Dergunova L.V. Investigation of the mechanism of the neuroprotective effect of the peptide preparation Semax in rat brain under conditions of ischemia-reperfusion. Medical Genetics. 2020;19(5):76-78. https://doi.org/10.25557/2073-7998.2020.05.76-78)
  10. Valieva L.V., Filippenkov I.B., Stavchansky V.V., Denisova A.E., Gubsky L.V., Limborska S.A., Dergunova L.V. A study of the expression of circular RNAs of the Ece1, Mvp, Egfem1, Cdyl and Rgs9 genes in transient cerebral ischemia model conditions. Medical Genetics. 2020;19(5):69-70. https://doi.org/10.25557/2073-7998.2020.05.69-70)
  11. Limborska SA, Filippenkov IB. // Circular RNA as a prospective molecular tool for the study of neuroprotection in cerebral ischemia. Transl Cancer Res, 2019;8(Suppl 2):S126-S129.doi: 10.21037/tcr.2018.12.03. http://tcr.amegroups.com/article/view/25774/html. Impact Factor 1.07.
  12. Filippenkov IB, Kolomin TA, Limborska SA, Dergunova LV // Developmental stage-specific expression of genes for sphingomyelin synthase in rat brain // Cell Tissue Res.,  2018, 372(1):33-40. DOI: 10.1007/s00441-017-2762-1. https://www.ncbi.nlm.nih.gov/pubmed/29294205. Impact Factor 4.04.
  13. Filippenkov IB, Sudarkina OY, Limborska SA, Dergunova LV // Multi-step splicing of sphingomyelin synthase linear and circular RNAs // Gene. 2018, 654:14-22. doi: 10.1016/j.gene.2018.02.030. https://www.ncbi.nlm.nih.gov/pubmed/29454087. Impact Factor: 2.984.
  14. Dergunova LV, Filippenkov IB, Stavchansky VV, Denisova AE, Yuzhakov VV, Mozerov SA, Gubsky LV, Limborska SA // Genome-wide transcriptome analysis using RNA-Seq reveals a large number of differentially expressed genes in a transient MCAO rat model // BMC Genomics. 2018;19(1):655. doi: 10.1186/s12864-018-5039-5. https://www.ncbi.nlm.nih.gov/pubmed/30185153. Impact Factor 3.594.
  15. Filippenkov IB, Stavchansky VV, Denisova AE, Ivanova KA, Limborska SA, Dergunova LV // Experimental cerebral ischemia affects the expression of circular RNA genes of metabotropic glutamate receptors mGluR5 and mGluR3 in rat brain // Russ. J. Bioorganic Chem, 2018, 3(44), с. pp 302–309), Impact Factor 0.752.
  16. Filippenkov IB, Limborska SA, Dergunova LV // Peculiarities of non-coding RNA functioning in the norm and cerebral ischemia // Genes & Cells 2018, Vol. XIII, № 1, pp. 42-46, DOI: 10.23868/201805004SJR 2016
  17. Filippenkov IB, Kalinichenko EO, Limborska SA, Dergunova LV // Circular RNAs-one of the enigmas of the brain // Neurogenetics, 2017, 18(1):1-6, doi: 10.1007/s10048-016-0490-4, https://www.ncbi.nlm.nih.gov/pubmed/27449796. Impact Factor 2.774.
  18. Filippenkov IB, Dergunova LV, Rozhkova AV, Sudarkina OYu, Limborska SА // Peculiarities of the structure and expression of human sphingomyelin synthase 1 gene (SGMS1) // Tsitologiya (Cell and Tissue Biology), 2016, 4(58): 267-271, http://www.tsitologiya.cytspb.rssi.ru/58_4/filippenkov.pdf. CiteScore: 0.30, Scopus.
  19. Sudarkina OY, Filippenkov IB, Brodsky IB, Limborska SA, Dergunova LV // Comparative analysis of sphingomyelin synthase 1 gene expression in human tissues at transcriptional and translational levels // Mol Cell Biochem, 2015, 406(1-2):91-9, doi: 10.1007/s11010-015-2427-x, https://www.ncbi.nlm.nih.gov/pubmed/25912551. Impact Factor 2.795.
  20. Rozhkova AV, Filippenkov IB, Sudarkina OY, Limborska SA, Dergunova LV // [Alternative promoters localised in SGMS1 gene introns take part in regulation of its expression in human tissues] // Mol Biol (Mosk). 2015; 49(2):325-33. https://www.ncbi.nlm.nih.gov/pubmed/26065260. Impact Factor 0.977.
  21. Filippenkov IB, Sudarkina OY, Limborska SA, Dergunova LV // Circular RNA of the human sphingomyelin synthase 1 gene: Multiple splice variants, evolutionary conservatism and expression in different tissues // RNA Biol, 2015, 12(9):1030-42, doi: 10.1080/15476286.2015.1076611, https://www.ncbi.nlm.nih.gov/pubmed/26274505. Impact Factor 5.350.