Filatova Elena Vladislavovna | Institute of Molecular Genetics

Filatova Elena Vladislavovna

Academic degree:
Doctor of Philosophy (Biology)

Academic title:
without academic rank


Division of IMG:
Laboratory of molecular genetics of hereditary diseases

Position:
Senior Researcher


Telephone:
+7-499-196-02-24

Е-mail:
filatovaev@img.msk.ru



Main research interests

Key areas of research - the study of molecular genetics, causes and mechanisms of neurodegenerative diseases major depressive disorder, hypertrophic cardiomyopathy, the study of mechanisms of action of synthetic analogues of regulatory peptides.
 
Main results.
Potential mRNA markers of early clinical stages of Parkinson's disease were identified. We have revealed reduction of expression of the ubiquitin-proteasome protein degradation system in mice with the MPTP-induced pre-symptomatic and early symptomatic stages of PD. Moreover, in 6-OHDA-induced rat model of PD we showed that synthetic peptides DNSP-5 and SD had potential neuroprotective properties and may stimulate the surviving DA neurons.



Teaching activities

Scientific adviser of five graduation works.



Publications

  1. Shadrina Maria I., Filatova Elena V., Karabanov Aleksey V., Slominsky Peter A., Illarioshkin Sergey N., Ivanova-Smolenskaya Irina A., Limborska Svetlana A., «Expression analysis of Suppression of Tumorigenicity 13 gene in patients with Parkinson Disease». Neuroscience Letters, 473(3), 2010, pp. 257–259, doi:10.1016/j.neulet.2010.02.061.
  2. E. V. Filatova · M. I. Shadrina · A. V. Karabanov · P. A. Slominsky · S. N. Illarioshkin · I. A. Ivanova-Smolenskaya · S. A. Limborska, Expression of GSK3B in peripheral blood of patients with Parkinson’s disease. Molecular Biology 06/2011; 45(3):417-420. DOI:10.1134/S0026893311020063.
  3. E V Filatova · M I Shadrina · E Iu Fedotova · P A Slominskiĭ · S N Illarioshkin · I A Ivanova-Smolenskaia · S A Limborskaia, Analysis of Single Nucleotide Polymorphism rs415430 in the WNT3 Gene in Parkinson's Disease in Russian Population. Molekuliarnaia genetika, mikrobiologiia i virusologiia 06/2011; 26(2):3-4. DOI:10.3103/S0891416811020042.
  4. Elena Filatova, Maria Shadrina, Petr Slominsky and Svetlana Limborska. Analysis of Transcriptome Alterations in Parkinson’s Disease. In Etiology and Pathophysiology of Parkinson's Disease. Edited by: Abdul Qayyum Rana. Pp. 293-316. Publisher: InTech, October 2011. ISBN 978-953-307-462-7
  5. Elena V. Filatova, Anelya Kh. Alieva, Maria I. Shadrina, Petr A. Slominsky. MicroRNAs: Possible role in pathogenesis of Parkinson’s disease. Biochemistry (Moscow) 08/2012; 77(8):813-9. DOI:10.1134/S0006297912080020
  6. Elena V. Filatova, Maria I. Shadrina, Ekaterina Y. Fedotova, Irina A. Ivanova-Smolenskaya, Sergei N. Illarioshkin, Svetlana A. Limborska, Petr A. Slominsky. Analysis of known point mutations and SNPs in genes responsible for monogenic Parkinson’s disease in Russian patients. Advances in Parkinson’s Disease, Vol.2, No.1, 28-30 (2013), doi:10.4236/apd.2013.21005, February 18, 2013.
  7. Maria I. Shadrina, Elena V. Filatova, Anelya Kh. Alieva, Alla V. Stavrovskaya, Rudolph M. Khudoerkov, Svetlana A. Limborska, Sergei N. Illarioshkin, Petr A. Slominsky. Transcriptome profiling of 6-OHDA model of Parkinson’s disease. Advances in Bioscience and Biotechnology, 2013, Vol. 4, № 6A, pp. 28-35, DOI: 10.4236/abb.2013.46A005.
  8. Anelya Kh. Alieva, Maria I. Shadrina, Elena V. Filatova, Vera V. Ustinova, Ekaterina Yu Fedotova, Alexey V. Karabanov, Sergey N. Illarioshkin, Petr A. Slominsky. Polymorphisms in the SNCA Gene: Association with the Risk of Development of the Sporadic Form of Parkinson’s Disease and the Level of SNCA Gene Expression in Peripheral Blood of Patients from Russia. Neuroscience & Medicine, 2013, 4, 208-214. Pub. Date: December 2, 2013. DOI: 10.4236/nm.2013.44032.
  9. E.V. Filatova, A.Kh. Alieva, M.I. Shadrina, M.V. Shulskaya, E.Yu. Fedotova, S.N. Illarioshkin, S.A. Limborska, P.A. Slominsky Analysis of mutations in patients with suspected autosomal dominant forms of Parkinson’s disease. Molecular Genetics Microbiology and Virology 04/2014; 29(1):1-3. DOI:10.3103/S0891416814010029.
  10. Filatova, EV; Shadrina, MI; Alieva, AK; Kolacheva, AA; Slominsky, PA; Ugrumov, MV. Expression analysis of genes of ubiquitin-proteasome protein degradation system in MPTP-induced mice models of early stages of Parkinson's disease. DOKLADY BIOCHEMISTRY AND BIOPHYSICS, Volume: 456  Issue: 1  Pages: 116-118. DOI: 10.1134/S1607672914030107
  11. Anelya Kh. Alieva, Maria I. Shadrina, Elena V. Filatova, Aleksey V. Karabanov, Sergey N. Illarioshkin, Svetlana A. Limborska, and Petr A. Slominsky. Involvement of Endocytosis and Alternative Splicing in the Formation of the Pathological Process in the Early Stages of Parkinson’s Disease. BioMed Research International, Volume 2014, Article ID 718732, 6 pages. http://dx.doi.org/10.1155/2014/718732
  12. Anelya Kh. Alieva, Elena V. Filatova, Aleksey V. Karabanov, Sergey N. Illarioshkin, Svetlana A. Limborska, Maria I. Shadrina, Petr A. Slominsky. miRNA expression is highly sensitive to a drug therapy in Parkinson's disease. Parkinsonism and Related Disorders, 2015, V 21, P 72-74.
  13. Anelya Kh. Alieva, Elena V. Filatova, Aleksey V. Karabanov, Sergey N. Illarioshkin, Petr A. Slominsky, and Maria I. Shadrina. Potential Biomarkers of the Earliest Clinical Stages of Parkinson’s Disease. Parkinson’s Disease, Volume 2015, Article ID 294396, 6 pages. http://dx.doi.org/10.1155/2015/294396
  14. Anelya Kh. Alieva, Elena V. Filatova, Anna A. Kolacheva, Margarita M. Rudenok, Petr A. Slominsky, Mikhail V. Ugrumov, Maria I. Shadrina. Transcriptome Profile Changes in Mice with MPTP-Induced Early Stages of Parkinson’s Disease. Mol Neurobiol (2016). doi:10.1007/s12035-016-0190-y. First Online: 18 October 2016. Impact Factor: 6.190
  15. Elena Filatova, Anastasiya Kasian, Timur Kolomin, Ekaterina Rybalkina, Anelya Alieva, Lyudmila Andreeva, Svetlana Limborska, Nikolay Myasoedov, Galina Pavlova, Petr Slominsky, Maria Shadrina. GABA, Selank, and Olanzapine Affect the Expression of Genes Involved in GABAergic Neurotransmission in IMR-32 Cells. Front. Pharmacol. 8:89. doi: 10.3389/fphar.2017.00089. Published: 28 February 2017. Impact Factor: 4.400
  16. Elena V. Filatova, Anelja Kh. Alieva, Maria I. Shadrina, Petr A. Slominsky. Differences in relative levels of 88 microRNAs in various regions of the normal adult human brain. MicroRNA, 2017, V. 6, No. 2, P 125 - 135. DOI: 10.2174/2211536606666170519141723
  17. Anelya Alieva, Margarita Rudenok, Elena Filatova, Alexey Karabanov, Olga Doronina, Kseniya Doronina, Anna Kolacheva, Mikhail Ugrumov, Sergey Illarioshkin, Petr Slominsky & Maria Shadrina. VCP expression decrease as a biomarker of preclinical and early clinical stages of Parkinson’s disease. Scientific Reports, volume 10, Article number: 827 (2020). doi:10.1038/s41598-020-57938-3